![]() Other medications that can't be combined include some anti-infective, anti-cancer, cardiovascular and urinary tract infection medications. Usually only a small fraction of the active drug enters the bloodstream, a process known as very low to intermediate bioavailability.ĭrugs that carry an interaction risk include Zocor and Lipitor, which are used to lower cholesterol Nifediac and Afditab, which lower blood pressure and some opioid pain relievers like oxycodone. Medications that are affected by the citrus juice are all taken orally and combine in the gastrointestinal tract with an enzyme called CYP3A4. So it's not surprising that these levels go from what we call therapeutic to toxic." He discovered the negative reactions that occur when grapefruit juice is combined with certain medications about two decades ago. "Taking one tablet with a glass of grapefruit juice is like taking 20 tablets with a glass of water," author David Bailey, a clinical pharmacologist at the Lawson Health Research Institute in London, Canada, said to the CBC. ![]() For example, a statin used to lower cholesterol called simvastatin created a 330 percent higher systemic concentration of the drug when the patient drank a 200-mL glass of grapefruit juice once a day for three days compared to when they just drank water. For people who drink grapefruit juice daily, it could magnify the adverse reaction. The negative interactions can even occur if grapefruit juice or similar substances are consumed hours before taking the pill, meaning even eating one grapefruit while taking a once-daily medication can have a negative effect. High concentrations of certain drugs can cause kidney damage, GI tract bleeding, respiratory failure, bone-marrow suppression in people with compromised systems and death. As a result, more of the active medication enters the bloodstream. Grapefruits - as well as Seville oranges used to make marmalade, limes and pomelos (but not typical oranges) - contain a chemical called furanocoumarins, which affects the way some medications are absorbed and metabolized in the gastrointestinal (GI) tract. Try to eat the same amount of these foods every day so the level of warfarin in your blood stays the same.What's more, there are more than 85 drugs in total that cause some kind of reaction when taken with grapefruit juice, according to the study. Broccoli, Brussels sprouts, kale, parsley, and spinach are some of the most common foods high in vitamin K. It can make the blood thinner less effective and put you at higher risk of a dangerous blood clot. People taking the drug warfarin - used to treat and prevent blood clots – need to be aware of how much vitamin K they are taking in. Talk to your doctor about other ways to manage your allergies if you take blood pressure medicine. ![]() These help with the sneezing and runny nose caused by allergies, but some of them can make medication for high blood pressure less effective and raise your heart rate. It can also make it harder for your body to take in and use iron. Those include aspirin, epinephrine (used to treat serious allergic reactions), and albuterol (taken by inhaler for breathing problems such as asthma). It also can make others stronger than they should be or cause dangerous side effects.Ĭoffee can weaken antipsychotic drugs like lithium and clozapine, but boost the effects - and side effects - of others. This makes certain drugs less effective or even useless, including some blood pressure and heart medicines. If you need an iron supplement, ask your doctor about taking it and your medication at different times. If you take this medication and a multivitamin, check to see if the vitamin has iron in it. ![]() This can lower the effects of Synthroid, a medicine that provides thyroid hormone when your body doesn’t make enough (a condition called hypothyroidism). It also can boost the power of some stimulant drugs, like methylphenidate (Ritalin). Most licorice sold as candy is artificially-flavored and is of no concern.ĭark chocolate, in particular, can weaken the effects of drugs meant to calm you down or make you sleep (Ambien). But glycyrrhizin, a chemical in licorice, can weaken the effect of some drugs, including cyclosporine, used to keep people who’ve had transplants from rejecting their new organs. Some people use licorice to help with digestion and some use it to flavor foods. ![]() If you’re taking antibiotics, ask your doctor or pharmacist about the foods or beverages you should avoid. Minerals like calcium and magnesium are part of the reason, along with the protein casein. Dairy Products (milk, yogurt, cheese) can make it harder for your body to process certain antibiotics. ![]()
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